John F. Worzalla

Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs

Bryan H. Norman, Chuan Shih, John E. Toth et al. · Journal of Medicinal Chemistry · 1996 · 118 citations

Molecular Regulation, Wortmannin Analogs, Chemical Biology +20

Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514.

Richard M. Schultz, Vinod F. Patel, John F. Worzalla et al. · PubMed · 1999 · 111 citations

Antitumor Activity, Chemoprevention Strategy, Thymidylate Synthase +16

Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma.

John L. Tonkinson, John F. Worzalla, C H Teng et al. · PubMed · 1999 · 97 citations

Tumor Biology, Ht29 Colon Carcinoma, Oncology +13

Augmentation of the therapeutic activity of lometrexol -(6-R)5,10-dideazatetrahydrofolate- by oral folic acid.

Teresa Alati, John F. Worzalla, C Shih et al. · PubMed · 1996 · 67 citations

Pharmaceutical Science, Therapeutic Activity, Pathology +17

Metabolism of hexamethylmelamine-ring-14C in rats and man.

John F. Worzalla, Bernard D. Kaiman, Bruce M. Johnson et al. · PubMed · 1974 · 62 citations

Plasma Half-life, Urinary Metabolites, Biochemistry +15