Concepedia

Lynn S. Gossett

LS

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Publications

11

Citations

1.1K

H-Index

10

Active since

1991

Affiliations

Eli Lilly (United States)(Current)

The Barbara Ann Karmanos Cancer Institute

Lynn S. Gossett is an author at Eli Lilly (United States) specializing in pharmacology, enzyme inhibition, and medicinal chemistry.

Publications per year

1991–1999

11

Publications

11

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.

C Shih, V J Chen, Lynn S. Gossett et al. · PubMed · 1997 · 565 citations

, , +14

Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase

Samuel Baldwin, Archie Tse, Lynn S. Gossett et al. · Biochemistry · 1991 · 101 citations

, , +8

Cell cycle effects of antifolate antimetabolites: implications for cytotoxicity and cytostasis

John L. Tonkinson, Philip Marder, Sherri L. Andis et al. · Cancer Chemotherapy and Pharmacology · 1997 · 82 citations

, , +14

Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs.

Lillian L. Habeck, L G Mendelsohn, C Shih et al. · Molecular Pharmacology · 1995 · 67 citations

, , +16

A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors.

Lillian L. Habeck, T A Leitner, Katherine A. Shackelford et al. · PubMed · 1994 · 58 citations

, , +8

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