Lynn S. Gossett

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.

C Shih, V J Chen, Lynn S. Gossett et al. · PubMed · 1997 · 565 citations

Multiple Folate-requiring Enzymes, Medicinal Chemistry, Biochemistry +14

Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase

Samuel Baldwin, Archie Tse, Lynn S. Gossett et al. · Biochemistry · 1991 · 101 citations

Cell cycle effects of antifolate antimetabolites: implications for cytotoxicity and cytostasis

John L. Tonkinson, Philip Marder, Sherri L. Andis et al. · Cancer Chemotherapy and Pharmacology · 1997 · 82 citations

Biochemistry, Cell Division, Medicine +11

Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs.

Lillian L. Habeck, L G Mendelsohn, C Shih et al. · Molecular Pharmacology · 1995 · 67 citations

A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors.

Lillian L. Habeck, T A Leitner, Katherine A. Shackelford et al. · PubMed · 1994 · 58 citations

Glycobiology, Chemical Biology, Pharmaceutical Chemistry +18