LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.

C Shih, V J Chen, Lynn S. Gossett, +15

PubMed

Multiple Folate-requiring EnzymesMedicinal ChemistryBiochemistryParent MonoglutamateMedicine +12

Synthesis, Pharmacological Characterization, and Molecular Modeling of Heterobicyclic Amino Acids Related to (+)-2-Aminobicyclo[3.1.0]hexane- 2,6-dicarboxylic Acid (LY354740):  Identification of Two New Potent, Selective, and Systemically Active Agonists for Group II Metabotropic Glutamate Receptors

James A. Monn, Matthew J. Valli, Steven M. Massey, +14

Journal of Medicinal Chemistry

Active AgonistsMglu ReceptorsPharmacotherapyChemical BiologyPharmaceutical Chemistry +14

In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin.

Richard M. Schultz, Ronald L. Merriman, Sherri L. Andis, +6

PubMed

Chemoprevention StrategyMitogenic SignalsImmunologyTumor BiologyMolecular Pharmacology +14

Cell cycle effects of antifolate antimetabolites: implications for cytotoxicity and cytostasis

John L. Tonkinson, Philip Marder, Sherri L. Andis, +4

Cancer Chemotherapy and Pharmacology

BiochemistryCell DivisionMedicineCell DeathSelective Toxicity +9

Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs.

Lillian L. Habeck, L G Mendelsohn, C Shih, +7

Molecular Pharmacology

Synthesis and Metabotropic Glutamate Receptor Activity of S-Oxidized Variants of (−)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate:  Identification of Potent, Selective, and Orally Bioavailable Agonists for mGlu2/3 Receptors

James A. Monn, Steven M. Massey, Matthew J. Valli, +11

Journal of Medicinal Chemistry

S-oxidized VariantsPharmacotherapyChemical BiologyTyrosine Residue Y236Molecular Pharmacology +16

Evaluation of new anticancer agents against the MIA PaCa-2 and PANC-1 human pancreatic carcinoma xenografts.

Richard M. Schultz, Ronald L. Merriman, John E. Toth, +7

PubMed

Mia Paca-2Chemoprevention StrategyPathologyMetronomic ChemotherapyMia Paca-2 Xenograft +15

A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors.

Lillian L. Habeck, T A Leitner, Katherine A. Shackelford, +6

PubMed

GlycobiologyChemical BiologyPharmaceutical ChemistryTumor BiologyMedicinal Chemistry +16

Total Synthesis of Seco (+)- and<i>ent</i>-(−)-Oxaduocarmycin SA:  Construction of the (Chloromethyl)indoline Alkylating Subunit by a Novel Intramolecular Aryl Radical Cyclization onto a Vinyl Chloride

Vinod F. Patel, Sherri L. Andis, Julia K. Enkema, +6

The Journal of Organic Chemistry

EngineeringBiochemistryNatural SciencesSubunits 14ADiversity-oriented Synthesis +10

Methyl Substitution of 2-Aminobicyclo[3.1.0]hexane 2,6-Dicarboxylate (LY354740) Determines Functional Activity at Metabotropic Glutamate Receptors:  Identification of a Subtype Selective mGlu2 Receptor Agonist

Carmen Domínguez, Lourdes Prieto, Matthew J. Valli, +8

Journal of Medicinal Chemistry

Mglu2/3 Receptor AntagonistMethyl SubstitutionMetabotropic Glutamate ReceptorsMolecular PhysiologyDetermines Functional Activity +12