Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 55.6K citations

Life Sciences, Cell Biology, Apoptosis +14

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.

C Shih, V J Chen, Lynn S. Gossett et al. · PubMed · 1997 · 565 citations

Medicine, Medicinal Chemistry, Pharmacology +14

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

A.L. Jackman, G A Taylor, William Gibson et al. · PubMed · 1991 · 359 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates.

Carmen J. Allegra, Bruce A. Chabner, J C Drake et al. · Journal of Biological Chemistry · 1985 · 333 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

Carmen J. Allegra, J C Drake, Jacques Jolivet et al. · Proceedings of the National Academy of Sciences · 1985 · 313 citations · Full text

Medicine, Oncology, Pharmacology +7