Concepedia

Negative Allosteric Modulation

Negative Allosteric Modulation is an allosteric regulatory mechanism in which a modulator binds to a site distinct from the protein's active site, inducing a conformational change that decreases the protein's activity or affinity for its primary ligand.

445

Publications

21K

Citations

2.9K

Authors

717

Institutions

Publications per year

2017–2026

182

Variants

Nam

Parents

Publications

445

Cannabidiol is a negative allosteric modulator of the cannabinoid CB <sub>1</sub> receptor

Robert B. Laprairie, Amina M. Bagher, Michael E. Kelly et al. · British Journal of Pharmacology · 2015 · 1K citations · Full text

, , +13

The anti‐epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA‐ and glycine‐gated currents

Grégory Hans, Laurent Nguyen, Véronique Rocher et al. · British Journal of Pharmacology · 2002 · 335 citations · Full text

, , +17

Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol‐dimethylheptyl at the type 1 and type 2 cannabinoid receptors

Mylyne Tham, Orhan Yılmaz, Mariam Alaverdashvili et al. · British Journal of Pharmacology · 2018 · 315 citations · Full text

, , +17

Enhanced ADP-glucose pyrophosphorylase activity in wheat endosperm increases seed yield

Eric D. Smidansky, Maureen Clancy, F. D. Meyer et al. · Proceedings of the National Academy of Sciences · 2002 · 313 citations

, , +17

Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism

Jill L. Silverman, Daniel G. Smith, Stacey J. Sukoff Rizzo et al. · Science Translational Medicine · 2012 · 253 citations

, , +16

1–5 of 445

Authors

2.9K

  1. CW
    Craig W. Lindsley

    Vanderbilt University, United States

    29 publications · 1.5K citations

    24

    h-index

  2. PJ
    P. Jeffrey Conn

    Vanderbilt University, United States

    29 publications · 1.5K citations

    24

    h-index

  3. CM
    Colleen M. Niswender

    Vanderbilt University, United States

    21 publications · 1.1K citations

    19

    h-index

  4. KA
    Kyle A. Emmitte

    Vanderbilt University, United States

    18 publications · 739 citations

    17

    h-index

  5. AL
    Alice L. Rodriguez

    Vanderbilt University, United States

    18 publications · 792 citations

    17

    h-index

1–5 of 2.9K

Institutions

717

  1. Vanderbilt University

    Nashville, United States

    21 h-index

    170 publications

    9.8K citations

  2. Vanderbilt University Medical Center

    Nashville, United States

    20 h-index

    223 publications

    11.7K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    18 h-index

    111 publications

    6.6K citations

  4. Monash University

    Melbourne, Australia

    17 h-index

    107 publications

    4.9K citations

  5. Inserm

    Paris, France

    15 h-index

    72 publications

    2.7K citations

  6. Roche (Switzerland)

    Basel, Switzerland

    12 h-index

    115 publications

    7.7K citations

  7. University of Copenhagen

    Copenhagen, Denmark

    12 h-index

    65 publications

    1.9K citations

  8. Université de Montpellier

    Montpellier, France

    10 h-index

    36 publications

    1.4K citations

1–8 of 717

Venues

  1. Journal of Biological Chemistry

    JBC · 22 publications · 1.7K citations

    21

    h-index

  2. Journal of Medicinal Chemistry

    25 publications · 1.1K citations

    21

    h-index

  3. Molecular Pharmacology

    22 publications · 1.3K citations

    18

    h-index

  4. British Journal of Pharmacology

    BJP · 13 publications · 2.2K citations

    13

    h-index

  5. 13

    h-index

1–5