Supercritical fluid carbon dioxide extraction of Nigella sativa (black cumin) seeds using taguchi method and full factorial design

Abstract

Introduction Nigella sativa (black cumin) seeds, a dicotyledon of Ranunculaceae family, have been used for thousands years as spice and food preservative [1-3]. Black cumin is an annual herbaceous plant widely grown in Mediterranean countries, Middle East, Eastern Europe and Western Asia. In Middle East, Northern Africa and India, it has