Concepedia

Rapamycin delays tumor development in murine livers by inhibiting proliferation of hepatocytes with DNA damage†

Laura Elisa Buitrago‐Molina, Deepika Pothiraju, Jutta Lamlé, Silke Marhenke, Uta Kossatz-Boehlert, Kai Breuhahn, Michael P. Manns, Nisar P. Malek, Arndt Vogel

Hepatology · 2009 · 43 citations · 19 references

DOI

Abstract

We provide evidence that mTOR inhibition has a substantial effect on sequential carcinogenesis and may offer an effective strategy to delay liver tumor development in patients at risk.

References

19

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

Markus Guba, Philipp von Breitenbuch, Markus Steinbauer et al. · Nature Medicine · 2002 · 1.7K citations

, , +9

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

Jamison L. Nourse, Eduardo Firpo, W. Michael Flanagan et al. · Nature · 1994 · 895 citations

, , +10

Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

Augusto Villanueva, Derek Y. Chiang, Pippa Newell et al. · Gastroenterology · 2008 · 722 citations · Full text

Focal Gains of <i>VEGFA</i> and Molecular Classification of Hepatocellular Carcinoma

Derek Y. Chiang, Augusto Villanueva, Yujin Hoshida et al. · Cancer Research · 2008 · 693 citations · Full text

Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I

Ken Overturf, Muhsen Al-Dhalimy, Robert M. Tanguay et al. · Nature Genetics · 1996 · 553 citations

, , +14