Concepedia

P21 Regulation

p21 Regulation is a molecular mechanism within the tumor suppressor pathway that specifically governs the induction and maintenance of cell cycle arrest in response to oncogenic stress by modulating the activity of the cyclin-dependent kinase inhibitor p21.

4.8K

Publications

357K

Citations

25.1K

Authors

3.4K

Institutions

Publications per year

2017–2026

838

Parents

Publications

4.8K

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

J. Wade Harper · Cell · 1993 · 5.7K citations

, , +14

p21 is a universal inhibitor of cyclin kinases

Yue Xiong, Gregory J. Hannon, Hui Zhang et al. · Nature · 1993 · 3.4K citations

, , +14

Requirement for p53 and p21 to Sustain G <sub>2</sub> Arrest After DNA Damage

Fred Bunz, Annie Dutriaux, Christoph Lengauer et al. · Science · 1998 · 2.8K citations

, , +17

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

Kornélia Polyák, Mong-Hong Lee, Hediye Erdjument‐Bromage et al. · Cell · 1994 · 2.1K citations

, , +15

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Pumin Zhang, J. Wade Harper, Stephen J. Elledge et al. · Cell · 1995 · 2.1K citations · Full text

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1–5 of 4.8K

Authors

25.1K

  1. MV
    Mikhail V. Blagosklonny

    Roswell Park Comprehensive Cancer Center, United States

    19 publications · 2.1K citations

    17

    h-index

  2. RH
    Robert H. Weiss

    University of California, Davis, United States

    17 publications · 929 citations

    16

    h-index

  3. AK
    Andrew Koff

    Memorial Sloan Kettering Cancer Center, United States

    16 publications · 4.3K citations

    15

    h-index

  4. YH
    Yung Hyun Choi

    Dong-Eui University, South Korea

    17 publications · 1.1K citations

    14

    h-index

  5. JC
    Jonathan Chernoff

    Fox Chase Cancer Center, United States

    15 publications · 1.8K citations

    14

    h-index

1–5 of 25.1K

Institutions

3.4K

  1. Harvard University

    Cambridge, United States

    61 h-index

    383 publications

    76.4K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    56 h-index

    189 publications

    102.9K citations

  3. National Institutes of Health

    Bethesda, United States

    49 h-index

    270 publications

    31.5K citations

  4. The University of Texas MD Anderson Cancer Center

    Houston, United States

    46 h-index

    376 publications

    37.1K citations

  5. National Cancer Institute

    Bethesda, United States

    45 h-index

    220 publications

    19.9K citations

  6. Baylor College of Medicine

    Houston, United States

    41 h-index

    195 publications

    52.9K citations

  7. Inserm

    Paris, France

    41 h-index

    380 publications

    23.2K citations

  8. Memorial Sloan Kettering Cancer Center

    New York, United States

    39 h-index

    160 publications

    34.9K citations

1–8 of 3.4K

Venues

  1. Journal of Biological Chemistry

    JBC · 282 publications · 30.4K citations

    102

    h-index

  2. Molecular and Cellular Biology

    MCB · 129 publications · 17.1K citations

    78

    h-index

  3. PubMed

    Repository · 311 publications · 21.2K citations

    76

    h-index

  4. Oncogene

    217 publications · 15.5K citations

    71

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 91 publications · 15.4K citations

    67

    h-index

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