Tumor Progression

Tumor progression is the process of sequential genetic and phenotypic alterations in neoplastic cell populations that confer progressively enhanced malignancy, manifested by increased autonomous proliferation, invasive capacity, and metastatic competence.

82.8K

Publications

5.5M

Citations

335.9K

Authors

15.5K

Institutions

Publications per year

2017–2026

30.5K

Parents

Cancer Biology

Children

AngiogenesisApoptosis ResistanceCancer Stem CellsCell Adhesion AlterationsCirculating Tumor CellsClonal EvolutionEpithelial-mesenchymal TransitionExtracellular Matrix RemodelingGenomic InstabilityHypoxia Adaptation

Publications

82.8K

Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer

Reiki Nishimura, Tomofumi Osako, Yasuyuki Nishiyama et al. · Oncology · 2013 · 13.2K citations · Full text

Medicine, Cancer Biology, Oncology +17

Sorafenib in Advanced Hepatocellular Carcinoma

Josep M. Llovet, Sergio Ricci, Vincenzo Mazzaferro et al. · New England Journal of Medicine · 2008 · 13K citations · Full text

Medicine, Oncology, Pharmacology +12

Signatures of mutational processes in human cancer

Ludmil B. Alexandrov, Serena Nik‐Zainal, David C. Wedge et al. · Nature · 2013 · 10.1K citations · Full text

Medicine, Cancer Biology, Oncology +14

Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer

Martin Reck, Delvys Rodríguez‐Abreu, Andrew Robinson et al. · New England Journal of Medicine · 2016 · 10.1K citations · Full text

Medicine, Oncology, Pharmacology +17

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

Dung T. Le, Jennifer N. Uram, Hao Wang et al. · New England Journal of Medicine · 2015 · 9.4K citations · Full text

Life Sciences, Immunology, Oncology +17

1–5 of 82.8K

Authors

335.9K

BI
Brian I. Rini
Cleveland Clinic, United States
122 publications · 15.8K citations
57
h-index
RJ
Robert J. Motzer
Memorial Sloan Kettering Cancer Center, United States
117 publications · 23.8K citations
57
h-index
JF
Jia Fan
Fudan University, China
117 publications · 10.1K citations
57
h-index
IJ
Isaiah J. Fidler
The University of Texas MD Anderson Cancer Center, United States
86 publications · 16.6K citations
55
h-index
JF
Judah Folkman
Boston Children's Hospital, United States
61 publications · 26.1K citations
51
h-index

1–5 of 335.9K

Institutions

15.5K

1–8 of 15.5K

Venues

PubMed
Repository · 6.8K publications · 432.2K citations
257
h-index
Journal of Clinical Oncology
1.5K publications · 196.1K citations
214
h-index
Cancer Research
1.7K publications · 210K citations
213
h-index
Proceedings of the National Academy of Sciences
PNAS · 660 publications · 124.7K citations
201
h-index
Clinical Cancer Research
1.1K publications · 135.9K citations
179
h-index

1–5

See also Tumor Progression
Molecular Mechanisms	Epithelial-mesenchymal Transition Warburg Effect Erk Signaling Genomic Instability Cellular Oncogenes Tumor Suppressor Genes Dna Repair Mechanisms E2f Transcription Factors Wnt Signaling Vegf-c Signaling
Microenvironment	Angiogenesis Tumor-associated Macrophages Cancer-associated Fibroblasts Cell-cell Interaction Mapping Tumor Immune Microenvironment Extracellular Matrix Remodeling Lymphocyte Exclusion Endothelial Cell Models
Phenotypic Changes	Epithelial-mesenchymal Transition Metabolic Reprogramming Apoptosis Evasion Cell Motility Phenotypic Plasticity
Therapeutic Resistance	Epithelial-mesenchymal Transition Drug Resistance Cancer Stem Cells Intratumoral Heterogeneity Intrinsic Resistance Mechanisms Cellular Dormancy Phenotypic Plasticity Evolutionary Game Theory Immunogenicity Of Genome Editors Metabolic Rewiring Compensatory Pathway Activation
Clinical Staging	Tnm Staging System Pretreatment Staging Histopathologic Staging Tumor Grading