Concepedia

Lymphocyte Exclusion

Lymphocyte Exclusion is a tumor-driven immunosuppressive mechanism in the context of cancer metastasis that restricts the infiltration of cytotoxic T cells into the tumor microenvironment, thereby enabling immune evasion by physically preventing adaptive immune responses from engaging malignant cells.

17

Publications

6.9K

Citations

183

Authors

46

Institutions

Publications per year

2017–2026

12

Variants

T-cell Exclusion

Parents

Publications

17

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang, Shengqing Gu, Deng Pan et al. · Nature Medicine · 2018 · 5.6K citations · Full text

, , +14

Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

Ivy X. Chen, Vikash P. Chauhan, Jessica M. Posada et al. · Proceedings of the National Academy of Sciences · 2019 · 398 citations · Full text

, , +17

Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6Clow F4/80+ Extratumoral Macrophages

Gregory L. Beatty, Rafael Winograd, Rebecca A. Evans et al. · Gastroenterology · 2015 · 288 citations · Full text

, , +16

Impact of Treatment-Related Lymphopenia on Immunotherapy for Advanced Non-Small Cell Lung Cancer

Yeona Cho, Sang Joon Park, Hwa Kyung Byun et al. · International Journal of Radiation Oncology*Biology*Physics · 2019 · 146 citations · Full text

, , +14

Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes

John A. Ligon, Woonyoung Choi, Gady Cojocaru et al. · Journal for ImmunoTherapy of Cancer · 2021 · 123 citations · Full text

, , +17

1–5 of 17

Authors

183

  1. LB
    Lawrence Boise

    Emory University, United States

    1 publications · 47 citations

    1

    h-index

  2. SG
    Shengqing Gu

    Dana-Farber Cancer Institute, United States

    1 publications · 5.6K citations

    1

    h-index

  3. JP
    Juyoung Park

    Florida Atlantic University, United States

    1 publications · 146 citations

    1

    h-index

  4. CC
    Craig C. Hofmeister

    The Ohio State University, United States

    1 publications · 47 citations

    1

    h-index

  5. EL
    Eva Lueerss

    University Medical Center Hamburg-Eppendorf, Germany

    1 publications · 24 citations

    1

    h-index

1–5 of 183

Institutions

46

  1. The University of Texas Southwestern Medical Center

    Dallas, United States

    2 h-index

    8 publications

    5.7K citations

  2. Harvard University

    Cambridge, United States

    2 h-index

    16 publications

    47.6K citations

  3. Nanostring Technologies (United States)

    Seattle, United States

    2 h-index

    5 publications

    148 citations

  4. Case Western Reserve University

    Cleveland, United States

    1 h-index

    3 publications

    99 citations

  5. University of Pennsylvania

    Philadelphia, United States

    1 h-index

    11 publications

    3.2K citations

  6. Massachusetts General Hospital

    Boston, United States

    1 h-index

    7 publications

    2.8K citations

  7. Emory University

    Atlanta, United States

    1 h-index

    13 publications

    611 citations

  8. National Cancer Institute

    Bethesda, United States

    1 h-index

    1 publications

    123 citations

1–8 of 46

Venues

  1. The Journal of Immunology

    JI · 2 publications · 67 citations

    2

    h-index

  2. Science Immunology

    1 publications · 27 citations

    1

    h-index

  3. 1

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 398 citations

    1

    h-index

  5. Disease Markers

    1 publications · 24 citations

    1

    h-index

1–5