Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang, Shengqing Gu, Deng Pan, +12

Nature Medicine

Cancer ImmunosurveillanceT Cell DysfunctionT-regulatory CellImmunologyTumor Immunity +8

Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients

Wen-Li Deng, Meiling Gao, Xinlan Lei, +10

Stem Cell Reports

Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α

Lijian Wu, Yiteng Jin, Xi Zhao, +9

Cell Metabolism

Immune EvasionCancer ImmunosurveillanceImmunologyTumor ImmunityImmune Regulation +9

Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis

Rongqing Pan, Jeremy Ryan, Deng Pan, +2

Cell

Mitochondrial ApoptosisCancer ImmunosurveillanceApoptosisImmunologyCell Death +5

The Integral Inner Nuclear Membrane Protein MAN1 Physically Interacts with the R-Smad Proteins to Repress Signaling by the Transforming Growth Factor-β Superfamily of Cytokines

Deng Pan, Luis D. Estévez-Salmerón, Shannon L. Stroschein, +4

Journal of Biological Chemistry

SclerostinMolecular RegulationSmad ProteinsCellular PhysiologyTranscriptional Regulation +18

Discovery of specialized NK cell populations infiltrating human melanoma metastases

Lucas Ferrari de Andrade, Yuheng Lu, Adrienne Luoma, +6

JCI Insight

Tumor-infiltrating Nk CellsCancer ImmunosurveillanceHuman Melanoma MetastasesMedicineMelanoma +11

Inhibition of MICA and MICB Shedding Elicits NK-Cell–Mediated Immunity against Tumors Resistant to Cytotoxic T Cells

Lucas Ferrari de Andrade, Sushil Kumar, Adrienne Luoma, +6

Cancer Immunology Research

COCO enhances the efficiency of photoreceptor precursor differentiation in early human embryonic stem cell-derived retinal organoids

Deng Pan, Xi-Xi Xia, Heng Zhou, +5

Stem Cell Research & Therapy

A Protein Tyrosine Phosphatase 1B Activity Inhibitor from the Fruiting Bodies of Ganoderma lucidum (Fr.) Karst and Its Hypoglycemic Potency on Streptozotocin-Induced Type 2 Diabetic Mice

Bao-Song Teng, Chen-Dong Wang, Hongjie Yang, +6

Journal of Agricultural and Food Chemistry

Structure characterization of a novel neutral polysaccharide isolated from Ganoderma lucidum fruiting bodies

Deng Pan, Linqiang Wang, Congheng Chen, +5

Food Chemistry

Ganoderma LucidumEngineeringBiochemistryNatural PolymerGlycobiology +7