Concepedia

Hypoxia Adaptation

Hypoxia Adaptation is a molecular and cellular response mechanism by which tumor cells reprogram their metabolism, gene expression, and signaling pathways to survive and proliferate under low oxygen tension.

22.1K

Publications

1.5M

Citations

91.2K

Authors

8K

Institutions

Publications per year

2017–2026

6K

Parents

Children

Publications

22.1K

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

, , +17

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

, , +17

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

, , +14

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

, , +16

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Dorit Shweiki, Ahuva Itin, Dov Soffer et al. · Nature · 1992 · 4.6K citations

, , +11

1–5 of 22.1K

Authors

91.2K

  1. GL
    Gregg L. Semenza

    Johns Hopkins University, United States

    158 publications · 69.5K citations

    106

    h-index

  2. AL
    Adrian L. Harris

    John Radcliffe Hospital, United Kingdom

    149 publications · 27.2K citations

    87

    h-index

  3. PJ
    Peter J. Ratcliffe

    University of Oxford, United Kingdom

    107 publications · 38.9K citations

    80

    h-index

  4. AJ
    Amato J. Giaccia

    Stanford University, United States

    87 publications · 19.9K citations

    61

    h-index

  5. RS
    Randall S. Johnson

    University of California San Diego, United States

    85 publications · 23.6K citations

    61

    h-index

1–5 of 91.2K

Institutions

8K

  1. Harvard University

    Cambridge, United States

    125 h-index

    1.5K publications

    253.2K citations

  2. Johns Hopkins University

    Baltimore, United States

    124 h-index

    1.4K publications

    384.7K citations

  3. Johns Hopkins Medicine

    Baltimore, United States

    118 h-index

    1K publications

    314K citations

  4. University of Pennsylvania

    Philadelphia, United States

    105 h-index

    1.1K publications

    158.9K citations

  5. University of Oxford

    Oxford, United Kingdom

    95 h-index

    1.6K publications

    196.1K citations

  6. Stanford University

    Stanford, United States

    95 h-index

    922 publications

    157.9K citations

  7. Inserm

    Paris, France

    91 h-index

    1.7K publications

    141K citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    90 h-index

    325 publications

    107.9K citations

1–8 of 8K

Venues

  1. Journal of Biological Chemistry

    JBC · 541 publications · 91.6K citations

    161

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 252 publications · 65.6K citations

    132

    h-index

  3. PubMed

    Repository · 854 publications · 68.6K citations

    124

    h-index

  4. Cancer Research

    287 publications · 37.8K citations

    115

    h-index

  5. Molecular and Cellular Biology

    MCB · 142 publications · 33.7K citations

    86

    h-index

1–5