David R. Mole

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

Redox Signaling, Molecular Physiology, Mammalian Homologs Define +11

Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

Matthew E. Cockman, Norma Masson, David R. Mole et al. · Journal of Biological Chemistry · 2000 · 1K citations · Full text

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

Jennifer S. Isaacs, Yun Jin Jung, David R. Mole et al. · Cancer Cell · 2005 · 935 citations · Full text

Urology, Renal Function, Fumarate Hydratase +6

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

Johannes Schödel, Spyros Oikonomopoulos, Jiannis Ragoussis et al. · Blood · 2011 · 719 citations