The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang, +7

Nature

Tumor BiologyHypoxia-inducible FactorsOxygen-dependent ProteolysisBiochemistryRedox Regulator +7

Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

Matthew E. Cockman, Norma Masson, David R. Mole, +7

Journal of Biological Chemistry

The epidermal growth factor–like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans

Martin Stacey, Gin-Wen Chang, John Q. Davies, +5

Blood

Disease-associated GPR56 Mutations Cause Bilateral Frontoparietal Polymicrogyria via Multiple Mechanisms

Nien‐Yi Chiang, Cheng‐Chih Hsiao, Yi-Shu Huang, +4

Journal of Biological Chemistry

Individual Gpr56 MutantsMultiple MechanismsGeneticsPathologyMolecular Biology +23

Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif

Gin-Wen Chang, Martin Stacey, Mark J. Kwakkenbos, +3

FEBS Letters

Molecular BiologyCellular PhysiologyGps MotifSpliced Emr2 IsoformSignaling Pathway +16

The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells

Mark J. Kwakkenbos, Gin-Wen Chang, Hsi‐Hsien Lin, +5

Journal of Leukocyte Biology

ImmunologyImmune RegulationImmunologic MechanismImmune SystemImmunotherapy +16

Heparin interacts with the adhesion GPCR GPR56, reduces receptor shedding, and promotes cell adhesion and motility

Nien‐Yi Chiang, Gin-Wen Chang, Yi-Shu Huang, +4

Journal of Cell Science

GPR56/ADGRG1 Activation Promotes Melanoma Cell Migration via NTF Dissociation and CTF-Mediated Gα12/13/RhoA Signaling

Nien‐Yi Chiang, Yen-Ming Peng, Horng‐Heng Juang, +4

Journal of Investigative Dermatology

Cancer ResearchCtf-mediated Gα12/13/rhoaSignal TransductionSignaling PathwayCell Regulation +10

CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells

Gin-Wen Chang, John Q. Davies, Martin Stacey, +7

Biochemical and Biophysical Research Communications

Developmental BiologyCell AdhesionCell-matrix InteractionHuman Adhesion-gpcr Emr2Medicine +4

Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα16/Akt/MAPK/NF-κB Signaling Pathways

I Kuan-Yu, Yi-Shu Huang, Ching-Hsun Hu, +6

Frontiers in Immunology