Concepedia

Mtor Signaling

mTOR Signaling is a intracellular signaling pathway that regulates cell growth, proliferation, and survival by integrating nutrient, energy, and growth factor signals through the mechanistic target of rapamycin kinase.

9.1K

Publications

740.9K

Citations

55.5K

Authors

5.9K

Institutions

Publications per year

2017–2026

3.7K

Variants

Mtor Pathway

Parents

Publications

9.1K

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

Dos D. Sarbassov, David A. Guertin, Siraj M. Ali et al. · Science · 2005 · 6.2K citations

, , +17

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Randy Strong, Z. Dave Sharp, James F. Nelson et al. · Nature · 2009 · 3.7K citations · Full text

, , +15

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Do‐Hyung Kim, Dos D. Sarbassov, Siraj M. Ali et al. · Cell · 2002 · 3K citations · Full text

, , +14

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Nanxin Li, Boyoung Lee, Rongjian Liu et al. · Science · 2010 · 2.9K citations · Full text

, , +17

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Yasemin Sancak, Timothy R. Peterson, Yoav D. Shaul et al. · Science · 2008 · 2.8K citations

, , +14

1–5 of 9.1K

Authors

55.5K

  1. DM
    David M. Sabatini

    Whitehead Institute for Biomedical Research, United States

    76 publications · 45.9K citations

    59

    h-index

  2. MN
    Michael N. Hall

    University of Basel, Switzerland

    46 publications · 9.8K citations

    37

    h-index

  3. CG
    Christopher G. Proud

    University of Dundee, United Kingdom

    44 publications · 4.8K citations

    36

    h-index

  4. DJ
    David J. Kwiatkowski

    Brigham and Women's Hospital, United States

    44 publications · 7.8K citations

    35

    h-index

  5. NS
    Nahum Sonenberg

    McGill University, Canada

    41 publications · 9K citations

    33

    h-index

1–5 of 55.5K

Institutions

5.9K

  1. Harvard University

    Cambridge, United States

    130 h-index

    1.5K publications

    293.8K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    97 h-index

    459 publications

    169.2K citations

  3. Inserm

    Paris, France

    71 h-index

    1.1K publications

    96.2K citations

  4. The University of Texas MD Anderson Cancer Center

    Houston, United States

    69 h-index

    978 publications

    103K citations

  5. University of Michigan

    Ann Arbor, United States

    66 h-index

    685 publications

    76.7K citations

  6. Brigham and Women's Hospital

    Boston, United States

    66 h-index

    526 publications

    76.9K citations

  7. University of Pennsylvania

    Philadelphia, United States

    65 h-index

    560 publications

    58.5K citations

  8. Memorial Sloan Kettering Cancer Center

    New York, United States

    65 h-index

    596 publications

    124.7K citations

1–8 of 5.9K

Venues

  1. Journal of Biological Chemistry

    JBC · 294 publications · 40.1K citations

    111

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 149 publications · 31.8K citations

    91

    h-index

  3. Cancer Research

    184 publications · 19.8K citations

    82

    h-index

  4. PLoS ONE

    302 publications · 20.8K citations

    74

    h-index

  5. Clinical Cancer Research

    106 publications · 10.7K citations

    66

    h-index

1–5