Randy Strong

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Randy Strong, Z. Dave Sharp, James F. Nelson et al. · Nature · 2009 · 3.7K citations · Full text

Education, Genetics, Nutrition +15

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

Patricia Spilman, Natalia Podlutskaya, Matthew J. Hart et al. · PLoS ONE · 2010 · 1K citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Richard A. Miller, Clinton M. Astle, Joseph A. Baur et al. · The Journals of Gerontology Series A · 2010 · 913 citations · Full text

Education, Pharmacology, Pharmacotherapy +16

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

Antonella Caccamo, Smita Majumder, Arlan Richardson et al. · Journal of Biological Chemistry · 2010 · 878 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Holly Van Remmen, Yuji Ikeno, Michelle M. Hamilton et al. · Physiological Genomics · 2003 · 733 citations

Life Sciences, Genetics, Molecular Biology +15