Bioorganic & Medicinal Chemistry Letters · 2011 · 25 citations · 16 references
MedicineMedicinal ChemistryPharmacologyGeneral PharmacologyMolecular PharmacologyPharmacodynamicsPotency Optimization
16
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
James Chen, Jussi Taipale, Michael K. Cooper et al. · Genes & Development · 2002 · 1.5K citations · Full text
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
Jussi Taipale, James Chen, Michael K. Cooper et al. · Nature · 2000 · 1.3K citations
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
Daniel D. Von Hoff, Patricia LoRusso, Charles M. Rudin et al. · New England Journal of Medicine · 2009 · 1.1K citations · Full text
Medicine, Oncology, Pharmacology +17
Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade
David M. Berman, Sunil Karhadkar, Andrew R. Hallahan et al. · Science · 2002 · 794 citations
Medicine, Oncology, Pharmacology +17