James Chen

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

James Chen, Jussi Taipale, Michael K. Cooper et al. · Genes & Development · 2002 · 1.5K citations · Full text

Life Sciences, Oncology, Pharmacology +13

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Jussi Taipale, James Chen, Michael K. Cooper et al. · Nature · 2000 · 1.3K citations

Medicine, Cancer Biology, Oncology +9

Structural basis for the binding of proline-rich peptides to SH3 domains

Hongtao Yu, James Chen, Sibo Feng et al. · Cell · 1994 · 1K citations

Life Sciences, Biochemistry, Molecular Biology +15

Small molecule modulation of Smoothened activity

James Chen, Jussi Taipale, Keith E. Young et al. · Proceedings of the National Academy of Sciences · 2002 · 996 citations

Life Sciences, Medicinal Chemistry, Pharmacology +13

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

Sibo Feng, James Chen, Hongtao Yu et al. · Science · 1994 · 807 citations

Life Sciences, Biochemistry, Molecular Biology +17