Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Chin Chiang, Ying Litingtung, Eric Lee et al. · Nature · 1996 · 3.1K citations

Life Sciences, Developmental Biology, Genetics +14

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

Heidi Hahn, Carol Wicking, Peter G. Zaphiropoulos et al. · Cell · 1996 · 2K citations · Full text

Medicine, Genetics, Molecular Genetics +16

Human Homolog of <b> <i>patched</i> </b> , a Candidate Gene for the Basal Cell Nevus Syndrome

Ronald L. Johnson, Alana Rothman, Jingwu Xie et al. · Science · 1996 · 1.9K citations

Life Sciences, Genetics, Oncology +17

Altered Neural Cell Fates and Medulloblastoma in Mouse <i>patched</i> Mutants

Lisa V. Goodrich, Ljiljana Milenković, Kay M. Higgins et al. · Science · 1997 · 1.7K citations

Life Sciences, Genetics, Molecular Genetics +17

Activating Smoothened mutations in sporadic basal-cell carcinoma

Jingwu Xie, Maximilien Murone, Shiuh-Ming Luoh et al. · Nature · 1998 · 1.3K citations

Veterinary Medicine, Genetics, Oncology +10