Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

James Chen, Jussi Taipale, Michael K. Cooper, +1

Genes & Development

Signal TransductionFluorescent DerivativesBiochemistrySteroidal Alkaloid CyclopamineMedicine +12

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

Marika J. Karkkainen, Paula Haiko, Kirsi Sainio, +9

Nature Immunology

Embryonic VeinsDevelopmental BiologyAngiogenesisFirst Lymphatic VesselsVascular Malformation +8

DNA-Binding Specificities of Human Transcription Factors

Arttu Jolma, Jian Yan, Thomas Whitington, +16

Cell

ChromatinTranscriptional RegulationNatural SciencesGeneticsGene Structure +9

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Jussi Taipale, James Chen, Michael K. Cooper, +5

Nature

Oncogenic MutationsGene TherapiesGenome InstabilitySomatic VariantOncogenic Agent +6

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, +15

Science

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

Emma Haapaniemi, Sandeep K. Botla, Jenna Persson, +2

Nature Medicine

Crispr–cas9 GenomeGene EditingGenome EditingMedicineCell Biology +1

Counting absolute numbers of molecules using unique molecular identifiers

Teemu Kivioja, Anna Vähärautio, Kasper Karlsson, +4

Nature Methods

Molecular CharacterizationAbsolute NumbersComputational BiologyMolecular BiologyMolecular Computing +2

Small molecule modulation of Smoothened activity

James Chen, Jussi Taipale, Keith E. Young, +2

Proceedings of the National Academy of Sciences

Developmental BiologySignal TransductionBiochemistryBiophysicsCell Signaling +13

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

Daniel Dumont, Lotta Jussila, Jussi Taipale, +5

Science

Blood Vessel DevelopmentHeart FailureDevelopmental BiologyAngiogenesisVascular Adaptation +13

Patched acts catalytically to suppress the activity of Smoothened

Jussi Taipale, Michael K. Cooper, Tapan Maiti, +1

Nature

CatalysisChemistryHomogeneous Catalysis