Michael K. Cooper

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

James Chen, Jussi Taipale, Michael K. Cooper et al. · Genes & Development · 2002 · 1.5K citations · Full text

Signal Transduction, Fluorescent Derivatives, Biochemistry +14

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Jussi Taipale, James Chen, Michael K. Cooper et al. · Nature · 2000 · 1.3K citations

Oncogenic Mutations, Gene Therapies, Genome Instability +8

Intertumoral Heterogeneity within Medulloblastoma Subgroups

Florence M.G. Cavalli, Marc Remke, Ladislav Rampášek et al. · Cancer Cell · 2017 · 1.2K citations · Full text

Biology, Neuro-oncology, Tumor Heterogeneity +7

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

Paul A. Northcott, David Shih, John Peacock et al. · Nature · 2012 · 910 citations · Full text

Genetics, Genomics, Cancer Biology +23

Teratogen-Mediated Inhibition of Target Tissue Response to <i>Shh</i> Signaling

Michael K. Cooper, Jeffery A. Porter, Keith E. Young et al. · Science · 1998 · 846 citations

Medicinal Chemistry, Signal Transduction, Developmental Biology +12