Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Shih-Min A. Huang, Yuji Mishina, Shanming Liu, +32

Nature

Tankyrase InhibitionSignal TransductionSignaling PathwayMolecular RegulationMedicine +5

Directed Differentiation of Embryonic Stem Cells into Motor Neurons

Hynek Wichterle, Ivo Lieberam, Jeffery A. Porter, +1

Cell

Embryonic Stem CellDevelopmental BiologyDirected DifferentiationMedicineMorphogenesis +5

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

Jeffery A. Porter, Keith E. Young, Philip A. Beachy

Science

Cholesterol ModificationDevelopmental BiologyOxysterolBiochemistryLipid Peroxidation +8

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Huai-Xiang Hao, Yang Xie, Yue Zhang, +16

Nature

SclerostinSignal TransductionSignaling PathwayWnt Receptor TurnoverReceptor (Biochemistry) +3

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

Henk Roelink, Jeffery A. Porter, C. Katherine Chiang, +4

Cell

Teratogen-Mediated Inhibition of Target Tissue Response to <i>Shh</i> Signaling

Michael K. Cooper, Jeffery A. Porter, Keith E. Young, +1

Science

Medicinal ChemistrySignal TransductionDevelopmental BiologyVeratrum AlkaloidsSterol Modification +10

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, Beat Nyfeler, Jane Nagel, +44

Nature Cell Biology

InflammationCell AutophagySignal TransductionHeme HomeostasisIron Metabolism +11

Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches

Robert Machold, Shigemi Hayashi, Michael Rutlin, +9

Neuron

BiologyEmbryonic Stem CellCell LineageDevelopmental BiologyMedicine +9

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach, +96

Cell

BioinformaticsTumor BiologyRadiation OncologyFunctional GenomicsProject Drive +11

Patterning activities of vertebrate hedgehog proteins in the developing eye and brain

Stephen C. Ekker, Anne R. Ungar, Penny Greenstein, +4

Current Biology

BiologyPattern FormationGanglion CellDevelopmental BiologyRetina +9