Huai-Xiang Hao

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Huai-Xiang Hao, Yang Xie, Yue Zhang et al. · Nature · 2012 · 955 citations

Sclerostin, Signal Transduction, Signaling Pathway +5

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 893 citations

Cancer Research, Allosteric Inhibition, Signal Transduction +12

Inactivating mutations of <i>RNF43</i> confer Wnt dependency in pancreatic ductal adenocarcinoma

Xiaomo Jiang, Huai-Xiang Hao, Joseph D. Growney et al. · Proceedings of the National Academy of Sciences · 2013 · 411 citations · Full text

SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors

Leila Dardaei, Hui Qin Wang, Manrose Singh et al. · Nature Medicine · 2018 · 198 citations · Full text

Alk Inhibitors, Medicine, Pharmacology +8

R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

Heinz Ruffner, Joëlle Sprunger, Olga Charlat et al. · PLoS ONE · 2012 · 171 citations · Full text

Signal Transduction, Molecular Physiology, Molecular Pathway +15