Huai-Xiang Hao

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Huai-Xiang Hao, Yang Xie, Yue Zhang et al. · Nature · 2012 · 976 citations

Life Sciences, Biochemistry, Molecular Biology +8

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 929 citations

Life Sciences, Cell Biology, Oncology +16

Inactivating mutations of <i>RNF43</i> confer Wnt dependency in pancreatic ductal adenocarcinoma

Xiaomo Jiang, Huai-Xiang Hao, Joseph D. Growney et al. · Proceedings of the National Academy of Sciences · 2013 · 421 citations · Full text

Medicine, Oncology, Pharmacology +17

SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors

Leila Dardaei, Hui Qin Wang, Manrose Singh et al. · Nature Medicine · 2018 · 202 citations · Full text

Medicine, Oncology, Pharmacology +16

Capmatinib (INC280) Is Active Against Models of Non–Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation

Sabrina Baltschukat, Barbara Schacher Engstler, Alan Huang et al. · Clinical Cancer Research · 2019 · 173 citations

Medicine, Oncology, Pharmacology +17