ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Huai-Xiang Hao, Yang Xie, Yue Zhang, +16

Nature

SclerostinSignal TransductionSignaling PathwayWnt Receptor TurnoverReceptor (Biochemistry) +3

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan, +50

Nature

Cancer ResearchAllosteric InhibitionSignal TransductionSignaling PathwayMedicine +10

Inactivating mutations of <i>RNF43</i> confer Wnt dependency in pancreatic ductal adenocarcinoma

Xiaomo Jiang, Huai-Xiang Hao, Joseph D. Growney, +16

Proceedings of the National Academy of Sciences

SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors

Leila Dardaei, Hui Qin Wang, Manrose Singh, +31

Nature Medicine

Alk InhibitorsMedicinePharmacologyBronchial NeoplasmImmune Checkpoint Inhibitor +6

R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

Heinz Ruffner, Joëlle Sprunger, Olga Charlat, +26

PLoS ONE

Signal TransductionMolecular PhysiologyMolecular PathwayMolecular RegulationOrphan Receptors Lgr4 +13

Capmatinib (INC280) Is Active Against Models of Non–Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation

Sabrina Baltschukat, Barbara Schacher Engstler, Alan Huang, +12

Clinical Cancer Research

6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors

Patrick Sarver, Michael Acker, Jeffrey T. Bagdanoff, +27

Journal of Medicinal Chemistry

Medicinal ChemistryAllosteric Shp2 InhibitorsDrug TargetEfficacious Shp2 InhibitorsBiochemistry +13

Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus

Hung Huynh, Huai-Xiang Hao, Stephen L. Chan, +16

Molecular Cancer Therapeutics

PathologyCancer BiologyTumor BiologyHcc PatientsPredicts Response +14

SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms

Ye Wang, Morvarid Mohseni, Angelo L. Grauel, +45

Scientific Reports

Differential responses of MET activations to MET kinase inhibitor and neutralizing antibody

Jianqun Kou, Phillip R. Musich, Ben Staal, +10

Journal of Translational Medicine