Ying-Nan P. Chen

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 893 citations

Cancer Research, Allosteric Inhibition, Signal Transduction +12

Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex

Maı̈na Lepourcelet, Ying-Nan P. Chen, Dennis S. France et al. · Cancer Cell · 2004 · 643 citations · Full text

Signal Transduction, Signaling Pathway, Natural Sciences +3

Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

Ying-Nan P. Chen, Sushil Sharma, Timothy M. Ramsey et al. · Proceedings of the National Academy of Sciences · 1999 · 318 citations · Full text

Apoptosis, Immunology, Cell Death +21

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen et al. · Journal of Medicinal Chemistry · 2016 · 284 citations · Full text

Allosteric Inhibition, Drug Target, Shp2 Inhibition +20

The unique N-terminal sequence of testis angiotensin-converting enzyme is heavily O-glycosylated and unessential for activity or stability

Mario R. Ehlers, Ying-Nan P. Chen, James Riordan · Biochemical and Biophysical Research Communications · 1992 · 52 citations

Unique N-terminal Sequence, Testis Angiotensin-converting Enzyme, Biochemistry +5