Ho Man Chan

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 893 citations

Cancer Research, Allosteric Inhibition, Signal Transduction +12

Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300

Steven R. Grossman, Maria E. Deato, Chrystelle Brignone et al. · Science · 2003 · 457 citations

A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation

Brittany C. Michel, Seth H. Cassel, Nazar Mashtalir et al. · Nature Cell Biology · 2018 · 417 citations

Non-canonical Swi/snf Complex, Oncogenic Agent, Medicine +9

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

Jacob D. Jaffe, Yan Wang, Ho Man Chan et al. · Nature Genetics · 2013 · 281 citations · Full text

Chromatin, Chromatin Structure, Chromatin Remodeling +8

Acetylation control of the retinoblastoma tumour-suppressor protein

Ho Man Chan, Marija Krstic–Demonacos, Linda Smith et al. · Nature Cell Biology · 2001 · 277 citations

Cell Regulation, Acetylation Control, Medicine +4