Matthew J. LaMarche - Concepedia

Author

Matthew J. LaMarche

Also Known As

M LAMARCHE, M Lamarche, M. J. LaMarche, M. Lamarche, Mathieu Lamarche, Matthew J LaMarche, Matthew J. LaMarche, Matthew LaMarche

156

Publications

3.9K

Citations

H-Index

Concepts

All Affiliations

Novartis (United States)Novartis (Switzerland)University of Pennsylvania Harvard University Novartis Institutes for BioMedical Research

About

Matthew J. LaMarche is an author at Novartis (United States) specializing in medicine, pharmacology, and drug discovery.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	21	21	2.4K
2	Natural Sciences	11	11	1K
3	Biochemistry	7	7	562
4	Engineering	5	5	377
5	Health Sciences	4	4	260

Matthew J. LaMarche

Publications

3.8K

Citations

H-Index

Page 1

	Year	Citations
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan, Nature Cancer ResearchAllosteric InhibitionSignal TransductionSignaling PathwayMedicine	2016	893
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen, Journal of Medicinal Chemistry Allosteric InhibitionDrug TargetShp2 InhibitionEfficacious Phosphatase InhibitorChemical Biology	2016	284
Evolution of a Gram-Scale Synthesis of (+)-Discodermolide Amos B. Smith, Thomas J. Beauchamp, Matthew J. LaMarche, Journal of the American Chemical Society Medicinal ChemistryDiversity Oriented SynthesisEngineeringNatural SciencesDiversity-oriented Synthesis	2000	236
Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer Matthew J. LaMarche, Michael Acker, Andreea Argintaru, Journal of Medicinal Chemistry	2020	207
SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors Leila Dardaei, Hui Qin Wang, Manrose Singh, Nature Medicine Alk InhibitorsMedicinePharmacologyBronchial NeoplasmImmune Checkpoint Inhibitor	2018	198
Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu Rowan P. Morris, Jennifer A. Leeds, Hans Ulrich Naegeli, Journal of the American Chemical Society Related Thiopeptide Ge2270aAntimicrobial Resistance GeneAntibioticsNatural SciencesDrug Discovery	2009	168
Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition Jonathan R. LaRochelle, Michelle Fodor, Vidyasiri Vemulapalli, Nature Communications	2018	162
Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling Chen Liu, Hengyu Lu, Hongyun Wang, Clinical Cancer Research	2020	156
Dual Allosteric Inhibition of SHP2 Phosphatase Michelle Fodor, Edmund V. Price, Ping Wang, ACS Chemical Biology	2018	127
Gram-Scale Synthesis of (+)-Discodermolide Amos B. Smith, Michael D. Kaufman, Thomas J. Beauchamp, Organic Letters	1999	121

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