Concepedia
Statistics
Publications
62
Citations
5.5K
H-Index
39
Active since
1979
Affiliations
University of Pennsylvania(Current)
Hospital of the University of Pennsylvania
Harvard University
Johns Hopkins University
Johns Hopkins Medicine
Michael Acker is an author at University of Pennsylvania specializing in medicine, molecular biology, and natural sciences.
Top concepts
MedicineNatural SciencesMolecular BiologyCardiologyHeart FailureAnesthesiologyBiochemistrySurgeryCell BiologyProtein Synthesis
Publications per year
1979–2023
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 893 citations
Cancer Research, Allosteric Inhibition, Signal Transduction +12
The Eukaryotic Translation Initiation Factors eIF1 and eIF1A Induce an Open Conformation of the 40S Ribosome
Lori A. Passmore, T.M. Schmeing, David Maag et al. · Molecular Cell · 2007 · 331 citations · Full text
Protein Biosynthesis, Molecular Biology, Open Conformation +4
Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer
Matthew J. LaMarche, Michael Acker, Andreea Argintaru et al. · Journal of Medicinal Chemistry · 2020 · 207 citations · Full text
Considerations for the design and reporting of enzyme assays in high-throughput screening applications
Michael Acker, Douglas S. Auld · Perspectives in Science · 2014 · 201 citations · Full text
Enzyme Assays, Hit Identification, Molecular Biology +20
Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin
Laura C. Brown, Michael Acker, Jon Clardy et al. · Proceedings of the National Academy of Sciences · 2009 · 194 citations · Full text
Bioorganic Chemistry, Engineering, Peptide Engineering +18
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