Mutational Signatures is a characteristic pattern of mutations in DNA arising from specific mutational processes, distinguished by its unique combination of mutation types, sequence context biases, and genomic distribution observed across cancer genomes.
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Aflatoxin SignaturesAging-associated Mutational SignaturesApobec Mutation SignaturesCancer-associated Mutational ProcessesCopy Number SignaturesCross-species Mutational SignaturesDeletion SignaturesDna Repair Deficiency SignaturesDoublet Base Substitution SignaturesHomologous Recombination Deficiency Signatures
Publications
3.2K
The Molecular Signatures Database Hallmark Gene Set Collection
Arthur Liberzon, Chet Birger, Helga Thorvaldsdóttir et al. · Cell Systems · 2015 · 14.5K citations · Full text
Signatures of mutational processes in human cancer
Ludmil B. Alexandrov, Serena Nik‐Zainal, David C. Wedge et al. · Nature · 2013 · 10.1K citations · Full text
Medicine, Cancer Biology, Oncology +14
Mutational heterogeneity in cancer and the search for new cancer-associated genes
Michael S. Lawrence, Petar Stojanov, Paz Polak et al. · Nature · 2013 · 5.7K citations · Full text
Maftools: efficient and comprehensive analysis of somatic variants in cancer
Anand Mayakonda, De‐Chen Lin, Yassen Assenov et al. · Genome Research · 2018 · 5.4K citations · Full text
COSMIC: the Catalogue Of Somatic Mutations In Cancer
John Tate, Sally Bamford, Harry Jubb et al. · Nucleic Acids Research · 2018 · 5.3K citations · Full text
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48
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- LBLudmil B. Alexandrov
University of California San Diego, United States
58 publications · 30.6K citations
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Harvard University
Cambridge, United States
80 h-index
686 publications
516K citations
Wellcome Sanger Institute
Cambridge, United Kingdom
76 h-index
1.4K publications
1.4M citations
University of Cambridge
Cambridge, United Kingdom
69 h-index
640 publications
451.4K citations
Memorial Sloan Kettering Cancer Center
New York, United States
63 h-index
964 publications
830.3K citations
Dana-Farber Cancer Institute
Boston, United States
63 h-index
511 publications
452K citations
The University of Texas MD Anderson Cancer Center
Houston, United States
54 h-index
805 publications
387.8K citations
Heidelberg University
Heidelberg, Germany
52 h-index
801 publications
828.6K citations
Broad Institute
Cambridge, United States
51 h-index
986 publications
1.3M citations
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- Proceedings of the National Academy of Sciences
PNAS · 108 publications · 13K citations
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- Nature Communications
99 publications · 12.5K citations
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- Nature Genetics
60 publications · 27K citations
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- Nature
75 publications · 58.7K citations
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- Blood
78 publications · 11.2K citations
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