Jesus M. Ontoria

Discovery of 2-{4-[(3<i>S</i>)-Piperidin-3-yl]phenyl}-2<i>H</i>-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors

Philip Jones, Sergio Altamura, Julia K. Boueres et al. · Journal of Medicinal Chemistry · 2009 · 315 citations · Full text

Medicine, Oncology, Pharmacology +16

2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors

Philip Jones, Matthew J. Bottomley, Ottavia Cecchetti et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 64 citations · Full text

Life Sciences, Chemistry, Medicinal Chemistry +9

Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy

Jesus M. Ontoria, Sergio Altamura, Annalise Di Marco et al. · Journal of Medicinal Chemistry · 2009 · 61 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors

Federica Orvieto, Danila Branca, Claudia Giomini et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 55 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +11

Identification and Biological Evaluation of a Series of 1<i>H</i>-Benzo[<i>de</i>]isoquinoline-1,3(2<i>H</i>)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors

Jesus M. Ontoria, Edwin H. Rydberg, Stefania Di Marco et al. · Journal of Medicinal Chemistry · 2009 · 45 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17