Potent Inhibitors of Subgenomic Hepatitis C Virus RNA Replication through Optimization of Indole-<i>N</i>-Acetamide Allosteric Inhibitors of the Viral NS5B Polymerase

Steven J. Harper, Salvatore Avolio, Barbara Pacini, +13

Journal of Medicinal Chemistry

Crystal StructureViral ReplicationViral Polymerase StructureViral Polymerase MechanismMolecular Biology +19

Discovery of (7<i>R</i>)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6<i>H</i>-indolo[1,2-<i>e</i>][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase

Frank Narjes, Benedetta Crescenzi, Marco Ferrara, +21

Journal of Medicinal Chemistry

Netupitant PET imaging and ADME studies in humans

Tulla Spinelli, Selma Calcagnile, Claudio Giuliano, +5

The Journal of Clinical Pharmacology

New ghrelin agonist, <scp>HM</scp>01 alleviates constipation and L‐dopa‐delayed gastric emptying in 6‐hydroxydopamine rat model of <scp>P</scp>arkinson's disease

Hiroshi Karasawa, Claudio Pietra, Claudio Giuliano, +5

Neurogastroenterology & Motility

Ghrelin receptor inverse agonists as a novel therapeutic approach against obesity‐related metabolic disease

Kathrin Abegg, Lara Bernasconi, Melanie Hutter, +5

Diabetes Obesity and Metabolism

An Easy Procedure for the Highly Regioselective Conversion of Epoxides to Halohydrins

Carlo Bonini, Claudio Giuliano, Giuliana Righi

Synthetic Communications

HalogenationEngineeringAlkene MetathesisBiochemistryNatural Sciences +12

Oral Treatment with the Ghrelin Receptor Agonist HM01 Attenuates Cachexia in Mice Bearing Colon-26 (C26) Tumors

Fabienne Olivia Villars, Claudio Pietra, Claudio Giuliano, +2

International Journal of Molecular Sciences

NutritionChemoprevention StrategyGastrointestinal PharmacologyImmunologyFood Intake +20

Synthesis and evaluation of novel phosphoramidate prodrugs of 2′-methyl cytidine as inhibitors of hepatitis c virus NS5B polymerase

Monica Donghi, Barbara Attenni, Cristina Gardelli, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryNovel Phosphoramidate ProdrugsBiochemistryHepatitis CMedicine +9

The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats

Tito Borner, Laura Loi, Claudio Pietra, +3

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Food IntakeAnorexia-cachexia SyndromeGastrointestinal Peptide HormoneMetabolic SyndromeHypothalamic Peptide +16

Cyclic phosphoramidates as prodrugs of 2′-C-methylcytidine

Malte Meppen, Barbara Pacini, Renzo Bazzo, +13

European Journal of Medicinal Chemistry

Bioorganic ChemistryHeterocyclicBiochemistryNatural SciencesOrganic Chemistry +3