New ghrelin agonist, <scp>HM</scp>01 alleviates constipation and L‐dopa‐delayed gastric emptying in 6‐hydroxydopamine rat model of <scp>P</scp>arkinson's disease

Abstract

6-OHDA rats display constipation- and adipsia-like features of PD and L-dopa-inhibited GE. The new orally active ghrelin agonist, HM01 crosses the blood-brain barrier and alleviates these alterations suggesting a potential benefit for PD with GI disorders.