Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +17

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Rupert P. Austin, Patrick Barton, Scott L. Cockroft et al. · Drug Metabolism and Disposition · 2002 · 407 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, Dermot F. McGinnity, Rupert P. Austin · Drug Metabolism and Disposition · 2005 · 370 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Development of a new permeability assay using low‐efflux MDCKII cells

Li Di, Carrie Whitney‐Pickett, John P. Umland et al. · Journal of Pharmaceutical Sciences · 2011 · 317 citations

Pharmacy, Cell Biology, Cell Biophysics +10

Cryopreserved human hepatocytes: characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug–drug interaction potential

Albert P. Li, Chuang Lu, Julie A Brent et al. · Chemico-Biological Interactions · 1999 · 298 citations

Pharmacy, Biochemistry, Pharmacology +17