Concepedia

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

Li Di, Christopher Keefer, Dennis O. Scott, Timothy J. Strelevitz, George Chang, Yi‐An Bi, Yurong Lai, Jonathon Duckworth, Katherine S. Fenner, Matthew D. Troutman,

European Journal of Medicinal Chemistry · 2012 · 149 citations · 30 references

DOI

Concepts

References

30

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Rupert P. Austin, Patrick Barton, Scott L. Cockroft et al. · Drug Metabolism and Disposition · 2002 · 399 citations

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, Dermot F. McGinnity, Rupert P. Austin · Drug Metabolism and Disposition · 2005 · 364 citations

Development of a new permeability assay using low‐efflux MDCKII cells

Li Di, Carrie Whitney‐Pickett, John P. Umland et al. · Journal of Pharmaceutical Sciences · 2011 · 311 citations

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Cryopreserved human hepatocytes: characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug–drug interaction potential

Albert P. Li, Chuang Lu, Julie A Brent et al. · Chemico-Biological Interactions · 1999 · 297 citations

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