Christopher Keefer

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

Li Di, Christopher Keefer, Dennis O. Scott et al. · European Journal of Medicinal Chemistry · 2012 · 149 citations

Systems Biology, Hepatology, Intrinsic Clearance Values +15

Evaluating the Differences in Cycloalkyl Ether Metabolism Using the Design Parameter “Lipophilic Metabolism Efficiency” (LipMetE) and a Matched Molecular Pairs Analysis

Antonia F. Stepan, Gregory W. Kauffman, Christopher Keefer et al. · Journal of Medicinal Chemistry · 2013 · 91 citations

Lipid Analysis, Medicinal Chemistry, Cycloalkyl Ether Metabolism +15

Extraction of tacit knowledge from large ADME data sets via pairwise analysis

Christopher Keefer, George Chang, Gregory W. Kauffman · Bioorganic & Medicinal Chemistry · 2011 · 64 citations

Engineering, Machine Learning, Knowledge Extraction +13

Interpretable, Probability-Based Confidence Metric for Continuous Quantitative Structure–Activity Relationship Models

Christopher Keefer, Gregory W. Kauffman, Rishi R. Gupta · Journal of Chemical Information and Modeling · 2013 · 45 citations

Systematic and Pairwise Analysis of the Effects of Aromatic Halogenation and Trifluoromethyl Substitution on Human Liver Microsomal Clearance

Hao Sun, Christopher Keefer, Dennis O. Scott · Drug Metabolism Letters · 2011 · 43 citations

Metabolomic Profiling, Medicinal Chemistry, Bioanalysis +23