Timothy J. Strelevitz

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

Paul S. Changelian, Mark E. Flanagan, Douglas J. Ball et al. · Science · 2003 · 670 citations · Full text

Medicine, Immunology, Pharmacology +17

Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

Mark E. Flanagan, Todd A. Blumenkopf, William H. Brissette et al. · Journal of Medicinal Chemistry · 2010 · 335 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

Li Di, Christopher Keefer, Dennis O. Scott et al. · European Journal of Medicinal Chemistry · 2012 · 154 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs

Raman Sharma, Timothy J. Strelevitz, Hongying Gao et al. · Drug Metabolism and Disposition · 2011 · 114 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Hydralazine As a Selective Probe Inactivator of Aldehyde Oxidase in Human Hepatocytes: Estimation of the Contribution of Aldehyde Oxidase to Metabolic Clearance

Timothy J. Strelevitz, Christine C. Orozco, R. Scott Obach · Drug Metabolism and Disposition · 2012 · 77 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15