Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

Paul S. Changelian, Mark E. Flanagan, Douglas J. Ball, +55

Science

ImmunologyCell DeathImmunotherapyInflammationTranslational Medicine +19

Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

Mark E. Flanagan, Todd A. Blumenkopf, William H. Brissette, +20

Journal of Medicinal Chemistry

ImmunologyJanus Tyrosine KinasesImmunotherapyInflammatory ArthritisInflammation +17

Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors

Mark E. Flanagan, J. A. Abramite, Dennis P. Anderson, +22

Journal of Medicinal Chemistry

Combinatorial ChemistryDrug TargetThiol-reactive Covalent InhibitorsChemistryChemical Biology +15

Identification of <i>N</i>-{<i>cis</i>-3-[Methyl(7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases

Michael L. Vazquez, Neelu Kaila, Joseph W. Strohbach, +32

Journal of Medicinal Chemistry

ImmunodeficienciesJanus KinasesImmunologyPharmacotherapyImmunotherapy +20

DNA-encoded chemical libraries

Alexander L. Satz, Andreas Brunschweiger, Mark E. Flanagan, +11

Nature Reviews Methods Primers

Nucleic Acid ChemistryBioorganic ChemistryNatural SciencesDna ReplicationMolecular Biology +3

Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support

Dillon T. Flood, Shota Asai, Xue‐Jing Zhang, +14

Journal of the American Chemical Society

On-DNA Decarboxylative Arylation: Merging Photoredox with Nickel Catalysis in Water

Dominik K. Kölmel, Jiang Ping Meng, Mei‐Hsuan Tsai, +5

ACS Combinatorial Science

Employing Photoredox Catalysis for DNA‐Encoded Chemistry: Decarboxylative Alkylation of α‐Amino Acids

Dominik K. Kölmel, Richard P. Loach, Thomas Knauber, +1

ChemMedChem

The specificity of JAK3 kinase inhibitors

Paul S. Changelian, Deborah Moshinsky, Cyrille Kuhn, +11

Blood

Paper- and computer-based workarounds to electronic health record use at three benchmark institutions

Mark E. Flanagan, Jason J. Saleem, L. G. Millitello, +2

Journal of the American Medical Informatics Association