Raman Sharma

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Andrew Fensome, Catherine M. Ambler, Eric P. Arnold et al. · Journal of Medicinal Chemistry · 2018 · 174 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria

Giancarlo A. Biagini, Nicholas Fisher, Alison E. Shone et al. · Proceedings of the National Academy of Sciences · 2012 · 159 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials

Edwin G. Tse, Sevan D. Houston, Craig M. Williams et al. · Journal of Medicinal Chemistry · 2020 · 149 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

Arthur C Rand, Siegfried S. F. Leung, Heather Eng et al. · MedChemComm · 2012 · 131 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

Rachel H. Clare, Catherine Bardelle, Paul Harper et al. · Nature Communications · 2018 · 130 citations · Full text

Pharmacy, Infectious Diseases, Medicinal Chemistry +17