Raman Sharma

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Andrew Fensome, Catherine M. Ambler, Eric P. Arnold et al. · Journal of Medicinal Chemistry · 2018 · 165 citations · Full text

Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria

Giancarlo A. Biagini, Nicholas Fisher, Alison E. Shone et al. · Proceedings of the National Academy of Sciences · 2012 · 156 citations

Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials

Edwin G. Tse, Sevan D. Houston, Craig M. Williams et al. · Journal of Medicinal Chemistry · 2020 · 137 citations · Full text

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

Arthur C Rand, Siegfried S. F. Leung, Heather Eng et al. · MedChemComm · 2012 · 131 citations

HIGHLY SELECTIVE INHIBITION OF HUMAN CYP3A IN VITRO BY AZAMULIN AND EVIDENCE THAT INHIBITION IS IRREVERSIBLE

David M. Stresser, Marc I. Broudy, Thuy Ho et al. · Drug Metabolism and Disposition · 2004 · 128 citations