Siegfried S. F. Leung

Author

University of California, San Francisco

Also Known As

S.S.F. Leung, Siegfried S F Leung, Siegfried S. F. Leung, Siegfried S.F. Leung

Publications

1.8K

Citations

H-Index

Concepts

All Affiliations

University of California, San Francisco Yale University University of California, Santa Cruz Pfizer (United States)Schrodinger (United States)

About

Siegfried S. F. Leung is an author at University of California, San Francisco specializing in biochemistry, medicine, and natural sciences.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	6	6	320
2	Biochemistry	6	6	759
3	Natural Sciences	5	5	705
4	Engineering	3	3	395
5	Biomedical Engineering	1	1	121

Siegfried S. F. Leung

Publications

1.8K

Citations

H-Index

Page 1

	Year	Citations
Methyl Effects on Protein–Ligand Binding Cheryl S. Leung, Siegfried S. F. Leung, Julian Tirado‐Rives, Journal of Medicinal Chemistry	2012	385
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds Tina R. White, Chad M. Renzelman, Arthur C Rand, Nature Chemical Biology Medicinal ChemistryBiochemistryNatural SciencesPeptide LibraryBioavailable Scaffolds	2011	373
Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products William M. Hewitt, Siegfried S. F. Leung, Cameron R. Pye, Journal of the American Chemical Society EngineeringPeptide EngineeringProtein FoldingBiophysicsPermeability Screening	2014	210
Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole Chiung-Kuang Chen, Siegfried S. F. Leung, Christophe Guilbert, PLoS neglected tropical diseases	2010	132
Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance Arthur C Rand, Siegfried S. F. Leung, Heather Eng, MedChemComm	2012	131
Testing Physical Models of Passive Membrane Permeation Siegfried S. F. Leung, Jona Mijalkovic, Kenneth Borrelli, Journal of Chemical Information and Modeling Membrane StructureExperimental Permeability MeasurementsMembrane FormationMembrane BiophysicsEngineering	2012	121
Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides Joshua Schwochert, Rushia Turner, Melissa Thang, Organic Letters Peptide EngineeringPeptide SciencePeptide TherapeuticsPeptide ChemistryAnalytical Ultracentrifugation	2015	84
Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators Markus Boehm, Kevin Beaumont, Rhys Jones, Journal of Medicinal Chemistry	2017	70
A Nonazole CYP51 Inhibitor Cures Chagas’ Disease in a Mouse Model of Acute Infection Patricia S. Doyle, Chiung-Kuang Chen, Jonathan B. Johnston, Antimicrobial Agents and Chemotherapy	2010	65
Simple Predictive Models of Passive Membrane Permeability Incorporating Size-Dependent Membrane-Water Partition Siegfried S. F. Leung, Dan Sindhikara, Matthew P. Jacobson Journal of Chemical Information and Modeling EngineeringMembrane CharacterizationSolution (Chemistry)Rrck AssaySolubility-diffusion Theory	2016	64

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