Alison E. Shone

Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria

Giancarlo A. Biagini, Nicholas Fisher, Alison E. Shone et al. · Proceedings of the National Academy of Sciences · 2012 · 159 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Identification of a 1,2,4,5‐Tetraoxane Antimalarial Drug‐Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins

Paul M. O’Neill, Richard K. Amewu, Gemma L. Nixon et al. · Angewandte Chemie International Edition · 2010 · 125 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2)

Chandrakala Pidathala, Richard K. Amewu, Bénédicte Pacorel et al. · Journal of Medicinal Chemistry · 2012 · 110 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Candidate Selection and Preclinical Evaluation of <i>N</i> - <i>tert</i> -Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century

Paul M. O’Neill, B. Kevin Park, Alison E. Shone et al. · Journal of Medicinal Chemistry · 2009 · 84 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles

Gemma L. Ellis, Richard K. Amewu, Sunil Sabbani et al. · Journal of Medicinal Chemistry · 2008 · 83 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14