Richard K. Amewu

Generation of quinolone antimalarials targeting the <i>Plasmodium falciparum</i> mitochondrial respiratory chain for the treatment and prophylaxis of malaria

Giancarlo A. Biagini, Nicholas Fisher, Alison E. Shone et al. · Proceedings of the National Academy of Sciences · 2012 · 159 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential

Thomas Antoine, Nicholas Fisher, Richard K. Amewu et al. · Journal of Antimicrobial Chemotherapy · 2013 · 146 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Paul A. Stocks, Patrick G. Bray, Victoria Barton et al. · Angewandte Chemie International Edition · 2007 · 130 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Identification of a 1,2,4,5‐Tetraoxane Antimalarial Drug‐Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins

Paul M. O’Neill, Richard K. Amewu, Gemma L. Nixon et al. · Angewandte Chemie International Edition · 2010 · 125 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting <i>Plasmodium falciparum</i> Type II NADH:Quinone Oxidoreductase (PfNDH2)

Chandrakala Pidathala, Richard K. Amewu, Bénédicte Pacorel et al. · Journal of Medicinal Chemistry · 2012 · 110 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17