Concepedia

Hepatic Clearance Differences

Hepatic Clearance Differences is a toxicokinetic construct that refers to interspecies variations in the rate and extent of drug elimination mediated by hepatic processes, primarily distinguished by differences in liver physiology, enzyme expression, and metabolic capacity across species.

146

Publications

7.7K

Citations

726

Authors

217

Institutions

Publications per year

2017–2026

13

Parents

Publications

146

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

Barbara A. Wetmore, John F. Wambaugh, Stephen Ferguson et al. · Toxicological Sciences · 2011 · 411 citations

, , +14

Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

Kenneth E. Thummel, Danny D. Shen, Terry Podoll et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 356 citations

, , +17

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

Y. Naritomi, Shigeyuki Terashita, Sumihisa Kimura et al. · PubMed · 2001 · 317 citations

, , +17

The effect of ageing on the hepatic clearance of propranolol.

CM Castleden, CF George · British Journal of Clinical Pharmacology · 1979 · 248 citations · Full text

, , +16

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

Yoichi Naritomi, Shigeyuki Terashita, Akira Kagayama et al. · Drug Metabolism and Disposition · 2003 · 187 citations

, , +17

1–5 of 146

Authors

726

  1. YL
    Yurong Lai

    Pfizer (United States), United States

    3 publications · 287 citations

    3

    h-index

  2. LD
    Li Di

    Pfizer (United States), United States

    3 publications · 294 citations

    3

    h-index

  3. AR
    Amin Rostami‐Hodjegan

    University of Manchester, United Kingdom

    3 publications · 329 citations

    3

    h-index

  4. LZ
    Leslie Z. Benet

    University of California, San Francisco, United States

    3 publications · 100 citations

    3

    h-index

  5. GT
    Geoffrey T. Tucker

    University of Sheffield, United Kingdom

    3 publications · 164 citations

    3

    h-index

1–5 of 726

Institutions

217

  1. University of Washington

    Seattle, United States

    6 h-index

    26 publications

    4.9K citations

  2. Vanderbilt University

    Nashville, United States

    5 h-index

    18 publications

    1.5K citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    4 h-index

    13 publications

    973 citations

  4. University of Manchester

    Manchester, United Kingdom

    4 h-index

    11 publications

    872 citations

  5. The University of Texas at San Antonio Health Science Center

    San Antonio, United States

    4 h-index

    14 publications

    635 citations

  6. University of California, San Francisco

    San Francisco, United States

    3 h-index

    8 publications

    336 citations

  7. Pfizer (United States)

    New York, United States

    3 h-index

    24 publications

    2.9K citations

  8. The University of Tokyo

    Tokyo, Japan

    3 h-index

    12 publications

    695 citations

1–8 of 217

Venues

  1. Drug Metabolism and Disposition

    16 publications · 1.2K citations

    16

    h-index

  2. PubMed

    Repository · 10 publications · 610 citations

    10

    h-index

  3. 9

    h-index

  4. Clinical Pharmacology & Therapeutics

    CPT · 9 publications · 631 citations

    9

    h-index

  5. Xenobiotica

    8 publications · 208 citations

    8

    h-index

1–5