Chuang Lu

The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America

Scott Grimm, Heidi J. Einolf, Steven D. Hall et al. · Drug Metabolism and Disposition · 2009 · 306 citations

Medicine, Pharmacokinetics, Pharmacology +17

Preclinical experimental models of drug metabolism and disposition in drug discovery and development

Donglu Zhang, Gang Luo, Xinxin Ding et al. · Acta Pharmaceutica Sinica B · 2012 · 302 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +11

Cryopreserved human hepatocytes: characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug–drug interaction potential

Albert P. Li, Chuang Lu, Julie A Brent et al. · Chemico-Biological Interactions · 1999 · 298 citations

Pharmacy, Biochemistry, Pharmacology +17

Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague–Dawley rat, minipig, and beagle dog

Chuang Lu, Albert P. Li · Chemico-Biological Interactions · 2001 · 203 citations

Medicine, Pharmacokinetics, Pharmacology +17

Comparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in Hepatocytes

Chuang Lu, Ping Li, Richard Gallegos et al. · Drug Metabolism and Disposition · 2006 · 141 citations

Pharmacy, Pharmacokinetics, Pharmacology +17