Concepedia

The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America

Scott Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng‐Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos,

Drug Metabolism and Disposition · 2009 · 306 citations · 50 references

DOI

Concepts

References

50

Esters of Methanesulfonic Acid as Irreversible Inhibitors of Acetylcholinesterase

Richard J. Kitz, Irwin B. Wilson · Journal of Biological Chemistry · 1962 · 1.5K citations · Full text

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Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan · Drug Metabolism and Disposition · 2006 · 456 citations

, , +17

The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 437 citations

, , +17

First-pass metabolism of cyclosporin by the gut

Joseph C. Kolars, Paul B. Watkins, Robert M. Merion et al. · The Lancet · 1991 · 428 citations · Full text

, , +11

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin*

Jack Gorski, D. I. Jones, B HAEHNERDANIELS et al. · Clinical Pharmacology & Therapeutics · 1998 · 411 citations

, , +14