Konstantine W. Skordos

The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America

Scott Grimm, Heidi J. Einolf, Steven D. Hall et al. · Drug Metabolism and Disposition · 2009 · 306 citations

Medicine, Pharmacokinetics, Pharmacology +17

Evaluation of Various Static In Vitro–In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug

Md L T Vieira, Brian J. Kirby, Isabelle Ragueneau‐Majlessi et al. · Clinical Pharmacology & Therapeutics · 2013 · 101 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Zafirlukast Metabolism by Cytochrome P450 3A4 Produces an Electrophilic α,β-Unsaturated Iminium Species That Results in the Selective Mechanism-Based Inactivation of the Enzyme

Kelem Kassahun, Konstantine W. Skordos, Ian McIntosh et al. · Chemical Research in Toxicology · 2005 · 72 citations

Medicine, Biochemistry, Pharmacology +17

The Metabolic Drug-Drug Interaction Profile of Dabrafenib: In Vitro Investigations and Quantitative Extrapolation of the P450-Mediated DDI Risk

Sarah K. Lawrence, Dung N. Nguyen, Chet Bowen et al. · Drug Metabolism and Disposition · 2014 · 52 citations

Medicine, Pharmacokinetics, Pharmacology +17

Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain

Yongzhen Qian, Emily Hua, Kheem S. Bisht et al. · Clinical & Experimental Metastasis · 2011 · 47 citations · Full text

Medicine, Cancer Biology, Oncology +14