Kheem S. Bisht

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

Hyunseok Kim, Krish Patel, Kristi Muldoon‐Jacobs et al. · Cancer Cell · 2010 · 791 citations · Full text

Reductive Stress, Tumor Biology, Mitophagy +7

<i>SIRT3</i> interacts with the <i>daf-16</i> homolog <i>FOXO3a</i> in the Mitochondria, as well as increases <i>FOXO3a</i> Dependent Gene expression

Kristi Muldoon Jacobs, J. Daniel Pennington, Kheem S. Bisht et al. · International Journal of Biological Sciences · 2008 · 271 citations · Full text

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity

Edward G. Mimnaugh, Wanping Xu, Michele D. Vos et al. · Molecular Cancer Therapeutics · 2004 · 210 citations · Full text

Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach

David Gius, Hengmi Cui, C. Matthew Bradbury et al. · Cancer Cell · 2004 · 182 citations

Chromatin, Systems Biology, Multimodality Approach +13

Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.

Kheem S. Bisht, C. Matthew Bradbury, David Mattson et al. · PubMed · 2003 · 178 citations

Heat Shock Protein, Tumor Biology, 17-Allylamino-17-demethoxygeldanamycin Potentiate +15