Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

Wanping Xu, Monica G. Marcu, Xitong Yuan, +3

Proceedings of the National Academy of Sciences

Molecular BiologyCancer BiologyTumor BiologySignaling PathwayCell Regulation +15

Sensitivity of Mature ErbB2 to Geldanamycin Is Conferred by Its Kinase Domain and Is Mediated by the Chaperone Protein Hsp90

Wanping Xu, Edward G. Mimnaugh, Meredith F.N. Rosser, +4

Journal of Biological Chemistry

Erbb2 SensitivityErbb ReceptorsMolecular BiologyTumor BiologySignaling Pathway +14

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

Soichiro Yoshida, Shinji Tsutsumi, Guillaume Mühlebach, +18

Proceedings of the National Academy of Sciences

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity

Edward G. Mimnaugh, Wanping Xu, Michele D. Vos, +5

Molecular Cancer Therapeutics

Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity

Mehdi Mollapour, Shinji Tsutsumi, Andrew W. Truman, +11

Molecular Cell

Signal TransductionBiochemistryNatural SciencesMolecular BiologyBiochemical Interaction +6

Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex

Wanping Xu, Xitong Yuan, Zhexin Xiang, +3

Nature Structural & Molecular Biology

Protein ChemistryHsp90 Chaperone ComplexBiochemistryProtein FoldingNatural Sciences +8

Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine

Wanping Xu, Mehdi Mollapour, Chrisostomos Prodromou, +11

Molecular Cell

Signal TransductionBiochemistryNatural SciencesHsp90-p50cdc37-aha1 Chaperone MachineMolecular Biology +5

Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors

Mehdi Mollapour, Dimitra Bourboulia, Kristin Beebe, +20

Molecular Cell

Protein FunctionSignal TransductionMolecular PathwayProtein FoldingAtp-competitive Inhibitors +7

Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase

Elana S. Ehrlich, Tao Wang, Kun Luo, +6

Proceedings of the National Academy of Sciences

Hsp90 Chaperone ComplexProtein FunctionHsp90 ClientHsp90 Client RegulationMolecular Regulation +10

Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation

Fumitaka Koga, Wanping Xu, Tatiana Karpova, +3

Proceedings of the National Academy of Sciences

Tumor BiologySrc KinaseSignal TransductionCell RegulationHsp90 Inhibitors +13