Xitong Yuan

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

Wanping Xu, Monica G. Marcu, Xitong Yuan et al. · Proceedings of the National Academy of Sciences · 2002 · 425 citations · Full text

Molecular Biology, Cancer Biology, Tumor Biology +17

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity

Edward G. Mimnaugh, Wanping Xu, Michele D. Vos et al. · Molecular Cancer Therapeutics · 2004 · 210 citations · Full text

Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex

Wanping Xu, Xitong Yuan, Zhexin Xiang et al. · Nature Structural & Molecular Biology · 2005 · 154 citations

Protein Chemistry, Hsp90 Chaperone Complex, Biochemistry +10

Endoplasmic Reticulum Vacuolization and Valosin-Containing Protein Relocalization Result from Simultaneous Hsp90 Inhibition by Geldanamycin and Proteasome Inhibition by Velcade

Edward G. Mimnaugh, Wanping Xu, Michele D. Vos et al. · Molecular Cancer Research · 2006 · 97 citations

The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.

Wanping Xu, Xitong Yuan, Yun Jin Jung et al. · PubMed · 2003 · 94 citations

Breast Oncology, Akt Activation, Cell Death +20