Edward G. Mimnaugh

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

Luke Whitesell, Edward G. Mimnaugh, B. de Costa et al. · Proceedings of the National Academy of Sciences · 1994 · 1.4K citations

Life Sciences, Molecular Biology, Pharmacology +14

Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway

Jennifer S. Isaacs, Yunjin Jung, Edward G. Mimnaugh et al. · Journal of Biological Chemistry · 2002 · 659 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

James P. Grenert, W. Patrick Sullivan, Patrick Fadden et al. · Journal of Biological Chemistry · 1997 · 570 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Polyubiquitination and Proteasomal Degradation of the p185c-B-2 Receptor Protein-tyrosine Kinase Induced by Geldanamycin

Edward G. Mimnaugh, Christine Chavany, Len Neckers · Journal of Biological Chemistry · 1996 · 465 citations · Full text

Life Sciences, Cancer Biology, Oncology +14

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

Wanping Xu, Monica G. Marcu, Xitong Yuan et al. · Proceedings of the National Academy of Sciences · 2002 · 430 citations

Life Sciences, Biochemistry, Molecular Biology +13