Len Neckers

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

Luke Whitesell, Edward G. Mimnaugh, B. de Costa et al. · Proceedings of the National Academy of Sciences · 1994 · 1.4K citations

Life Sciences, Molecular Biology, Pharmacology +14

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

Jennifer S. Isaacs, Yun Jin Jung, David R. Mole et al. · Cancer Cell · 2005 · 942 citations · Full text

Medicine, Biochemistry, Oncology +13

Characterization of oligonucleotide transport into living cells.

S.L. Loke, C.A. Stein, X H Zhang et al. · Proceedings of the National Academy of Sciences · 1989 · 740 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis

Yunjin Jung, Jennifer S. Isaacs, Sunmin Lee et al. · The FASEB Journal · 2003 · 675 citations

Medicine, Cancer Biology, Oncology +17

Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness

Brenda K. Eustace, Takashi Sakurai, Jean K. Stewart et al. · Nature Cell Biology · 2004 · 595 citations

Life Sciences, Cell Biology, Oncology +12