HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

Jennifer S. Isaacs, Yun Jin Jung, David R. Mole, +10

Cancer Cell

UrologyRenal FunctionFumarate HydrataseGenitourinary CancerMedicine +4

IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis

Yunjin Jung, Jennifer S. Isaacs, Sunmin Lee, +2

The FASEB Journal

Hif-1alpha ProteinImmunologyImmune RegulationCancer BiologyTumor Biology +14

Curcumin is an Inhibitor of p300 Histone Acetylatransferase

Len Neckers, Jane B. Trepel, Sunmin Lee, +4

Medicinal Chemistry

ChromatinMedicinal ChemistrySoutheast AsiaChemoprevention StrategyChromatin Remodeling +11

Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations

Fatima Karzai, David James VanderWeele, Ravi A. Madan, +24

Journal for ImmunoTherapy of Cancer

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

Soichiro Yoshida, Shinji Tsutsumi, Guillaume Mühlebach, +18

Proceedings of the National Academy of Sciences

Sunitinib in patients with chemotherapy-refractory thymoma and thymic carcinoma: an open-label phase 2 trial

Anish Thomas, Arun Rajan, Arlene Berman, +15

The Lancet Oncology

Open-label Phase 2OncologyClinical TrialsImmune Checkpoint InhibitorDermatology +4

Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity

Mikako Ogawa, Yusuke Tomita, Yuko Nakamura, +13

Oncotarget

Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of Carcinogenesis

Mercedes Garayoa, Alfredo Martı́nez, Sunmin Lee, +8

Molecular Endocrinology

The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

Wing‐Hang Tong, Carole Sourbier, Gennady Kovtunovych, +15

Cancer Cell

UrologyRenal FunctionKidney ResearchGlycolytic ShiftPathology +3

Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappaB activation

Yunjin Jung, Jennifer S. Isaacs, Sunmin Lee, +3

Biochemical Journal