Peter Fekkes

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 893 citations

Cancer Research, Allosteric Inhibition, Signal Transduction +12

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, Beat Nyfeler, Jane Nagel et al. · Nature Cell Biology · 2014 · 715 citations

Inflammation, Cell Autophagy, Signal Transduction +13

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

Michael Seiler, Akihide Yoshimi, Rachel Darman et al. · Nature Medicine · 2018 · 491 citations · Full text

Tumor Biology, Medicine, Rna Splicing +9

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

Rachel Darman, Michael Seiler, Anant A. Agrawal et al. · Cell Reports · 2015 · 453 citations · Full text

Genetics, Rna Splicing, Molecular Biology +17

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen et al. · Journal of Medicinal Chemistry · 2016 · 284 citations · Full text

Allosteric Inhibition, Drug Target, Shp2 Inhibition +20